The "Capsular" company's specialists has developed technology and creator-owned equipment for encapsulation of hydrophilic systems, i.e. emulsions, dispersions, suspensions and colloidal solutions, to produce capsules with innovative properties. Novelty of this development is that today it is the first precedent of encapsulation of materials containing the water component. Technology of encapsulation of fatty (hydrophobic) systems in the gelatin shell is widely used all around the world. Until now nobody has managed to encapsulate «water» with obtaining of heat-resistant capsules for long-term storage.

Capsules have spherical, or nearly spherical, geometric shape and diameter from 1.5 to 10.0 mm. In its structure the invention is characterized by presence of internal contents and the gel-like shell of a specified thickness, which comprises calcium alginate. Internal contents of the capsule is a hydrophilic substance or emulsion, aqueous suspension or dispersion.
Substances with various physical and chemical properties can be encapsulated; capsular products can be used in pharmaceutical, food, chemical, photographic, textile, petrochemical industry, as well as in medicine, agriculture and biotechnology.

Shells of capsules withstand technological processing, mechanical impact (intensive mixing), heat treatment (pasteurization or sterilization for 210 to 260 min at temperature of 130 °C under condition of compensating pressure), blending with other food ingredients, long-term storage (shelf life capsules determined only by properties of the inner filler).

A controlled release of encapsulated substances in environment due to diffusion through the capsule shell at a given speed (for example, of the biologically active or medicinal substance in the desired area of the body). has been achieved.

Models of capsules with a variety of properties have been developed. The main models are:

  • single-layer models - with a single shell on the basis of sodium alginate (for encapsulation of hydrophilic substances);
  • multi-layer (up to three shells) models - the outer shell is made of gelatin, the inner shell is alginic (for encapsulation of hydrophobic and surface active substances);
  • the «capsules-in-gel» model, where capsule shells «accrete» with gel, forming a monolithic structure of a given thickness (it is possible to create a porous or impervious system), while maintaining stability when exposed to gastric juice and gastric enzymes. The system is only destroyed under condition of ingress into the pancreas (at alkaline pH) (for different types of insulin: normal, fast and prolonged in the same container).

Depending on the tasks it is possible:

  1. to obtain capsule products with specified physical and structural-mechanical characteristics, such as size of capsules, shell thickness, ratio of internal content and shell, breaking strength, modulus of instantaneous elasticity, etc.
  2. to set specified dimensioning specifications (from 1.0 to 10.0 mm).
  3. to set a predetermined ratio of the shell to internal contents of capsules (from 5:95 to 50:50).
  4. to confer specified characteristics to shells (thickness, structure, permeability, strength, elasticity, stability to enzymes, pepsin, gastric juice, temperature, pressure, etc).

Encapsulated products are offered as one of the means of directed delivery of nutrients or drugs to specific parts of the body (gastrointestinal tract, pancreas, intestine and colon), providing maximum bioavailability, increasing medical and biological effectiveness.

The peculiarity of the capsule is programmable discharge of content of the capsules in the desired area of the body.
The shell has an immunostimulating, antiallergenic and anti-inflammatory action, binds exogenous and endogenous compounds, in particular salts of heavy metals and radionuclides, in the gastrointestinal tract of humans, serves as a means of detoxification of the human body and possesses curative and preventive properties.